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Product Description

Ultimate Guide to Vetoryl

Meet the Cushing's Disease Treatment: Vetoryl!

Vetoryl is the only FDA-approved treatment and veterinarian-prescribed dog medication that is used for the treatment of hyperadrenocorticism in dogs (Cushing's disease) to enhance diagnosed canines' vitality and quality of life. Vetoryl capsules are once-daily oral tablets that control the adrenal gland's excess production of cortisol.

How does Vetoryl work?

Vetoryl is a dog medication that contains one active ingredient - Trilostane (brand Vetoryl's generic name) that regulates the adrenal gland's excess production of cortisol.

By regulating steroid cortisol production, Trilostane for dogs calms the amount of the cortisol hormone released into the bloodstream during times of stress which leads to improvement in canine's Cushing's syndrome or hyperadrenocorticism (HAC). This happens with Vetoryl's inhibition of the enzyme 3s-hydroxysteroid dehydrogenase.

Outside of surgical treatment, Vetoryl capsules for dogs is a very popular treatment against two types of hyperadrenocorticism but cannot cure Cushing's syndrome. However, it enhances diagnosed canines' vitality and quality of life.

How is Vetoryl for dogs administered?

Vetoryl is administered orally, once daily, with food and protects your dog for the next 24 hours. Vetoryl Capsules cannot be opened or split. Once treatment has started, dog owners must monitor the dog's demeanor, appetite, and water intake. Some might consider twice daily dosages, according to their veterinarian's instructions.

The starting daily dose is one to three milligrams (mg) per pound for the treatment of hyperadrenocorticism in dogs. Available are five strengths, including 5 mg, 10 mg, 30 mg, 60 mg, and 120 mg capsules (each bottle comes with Vetoryl mg 30 ct capsules).

See the below Vetoryl dosing chart of a starting dose of 1, 2, or 3 milligrams (mg) per pound, using the example if the dog is 5 lbs.:

1 mg 2 mg 3 mg
Vetoryl 5 mg Vetoryl 10 mg Vetoryl 15 mg
Vetoryl 10 mg Vetoryl 20 mg Vetoryl 30 mg
Vetoryl 30 mg Vetoryl 60 mg Vetoryl 90 mg
Vetoryl 60 mg Vetoryl 120 mg Vetoryl 180 mg
Vetoryl 120 mg Vetoryl 240 mg Vetoryl 360 mg

What are the precautions of which you should be aware?

Vetoryl should not be given to dogs that are pregnant, lactating, have kidney dysfunction, and have liver disease. Vectoryl should only be used by dogs that are allergic to Trilostane.

The following medications, vitamins, and/or supplements can have a negative interaction with Vetoryl (i.e., Trilostane) is already taken by the dog: ACE inhibitors (e.g., benazepril or enalapril), aminoglutethimide, ketoconazole, mitotane, potassium-sparing diuretics (e.g., spironolactone), and potassium supplements.

What are the side effects of Vetoryl for dogs of which you should be aware?

Vetoryl's common reactions are vomiting, lethargy, decreased appetite, diarrhea, Addison's Disease, Addisonian Crisis, polydipsia, polyuria, weakness, shaking, and a variety of conditions due to pre-existing liver or kidney issues (e.g., elevated liver enzymes, elevated potassium, elevated BUN, elevated creatinine levels).

Other dog sensitivities from allergic reactions could occur, such as hives, difficulty breathing, or swelling of lips, tongue, or face. Seek emergency veterinary medical attention (and discontinue use)!

Increased future dosage's rare side effects are hypoadrenocorticism.

Frequently Asked Questions
  1. What do the Vetoryl for dogs reviews say?

    Vetoryl for dogs reviews rate 5 out of 5 stars. Most reviewers say that Vetoryl is regulating their dog's glucose level and improving their furry best friend's Cushing Disease.

  2. How long does it take for Vetoryl to work?

    It can be a variety of reactions within different dogs. Trilostane medication can take effect within 1 to 2 days. In clinical studies, activity levels began to show improvement within 14 days, or weeks, of treatment. Other clinical signs may take 3 to 6 months to improve. One reviewer monitored improvements in one year.

  3. Can a dog experience a Trilostane overdose?

    Serious levels of ingested Vetoryl Capsules may cause a Trilostane overdose resulting in toxicity symptoms or even death! If you suspect if this happens accidentally or inadvertently, you must contact your veterinarian, run to the emergency veterinary clinic, A.S.P.C.A.'s Animal Poison Control Center, or National Capital Poison Center.

  4. What is Vetoryl for dogs?

    Vetoryl is a treatment of a dog's hyperadrenocorticism (Cushing's disease) to enhance vitality and quality of life. Vetoryl controls the adrenal gland's excess production of cortisol. Vetoryl usual improvements are decreased appetite, decreased thirst, decreased frequency of urination, decreased panting, and elevated activity.

  5. What does Vetoryl do for dogs?

    Vetoryl Capsules for dogs (Trilostane) are the only FDA-approved treatment available for both pituitary-dependent hyperadrenocorticism (PDH) and adrenal-dependent hyperadrenocorticism (ADH). Although the daily administration of Vetoryl does not offer a medical cure for Cushing's syndrome, it may allow the disease to be managed successfully.

Concluding Thoughts

The most important thing that you should know about Vetoryl is that it is an effective treatment for a dog's hyperadrenocorticism (Cushing's disease) by regulating the adrenal gland's excess production of steroid cortisol and enhances the dog's vitality and quality of life.

DISCLAIMER: FDA law restricts Vetoryl only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition.

Side Effects & Warnings

Do not give your dog Vetoryl is they have any kidney or liver diseases. Vetoryl should not be given to dogs who are pregnant. If your dog suffers an allergic reaction such as hives, swelling of lips, tongue or face or difficulty breathing while taking Vetoryl, seek immediate emergency veterinary medical attention and discontinue dosages.

Less serious side effects such as unexpected decrease in appetite, vomiting, diarrhea, and lethargy may occur. Call your veterinarian if you see any side effects that seems unusual or bothersome to the animal while they are taking Vetoryl.


Vetoryl contains the active ingredient Trilostane


Vetoryl dosage is based on your dog’s weight. Follow directions as prescribed by your veterinarian. Vetoryl capsules should be taken with food.

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