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Product Description

Meet the Powerful Parasite Protector: Trifexis!

Trifexis is the veterinarian-approved dog medication that protects your dogs from various dangerous tiny parasites, internal and external. Trifexis is a monthly, chewable oral tablet that also prevents vicious heartworm disease. Trifexis ensures that your pup is in the best lovable condition that he or she can be.

How does Trifexis work?

Trifexis is a medication with two active ingredients (Spinosad and Milbemycin Oxime). Spinosad is known to prevent and control flea infestations. Spinosad paralyzes the flea through the insect's nervous system and eventually kills the flea.

The second active ingredient, milbemycin oxime, prevents heartworm disease and effectively controls three dangerous intestinal worms (i.e., adult roundworms, hookworms, and whipworms). Milbemycin Oxime is a powerful parasiticide and 100% effective heartworm preventative for the heartworm's immature form called Dirofilaria immitis that is transmitted by a mosquito.

How is Trifexis administered?

Trifexis is administered orally once a month and protects your dog for the next 30 days. These beef-flavored chewable tablets are artificially made from pork-based proteins and hydrolyzed soy. The chewable tablets can be used as dog treats or, most effectively, eaten with the dog's food.

What are the potential side effects of which you should be aware?

Be wary of the use of Trifexis in pregnant or breeding female dogs and epileptic dogs. Trifexis can be toxic if combined with other medications such as medications that contain the ingredient ivermectin (found in Heartgard Plus which is another effective heartworm preventative).

Test for heartworm disease before using Trifexis. The final dose must be given no fewer than three months following the last exposure to mosquitoes. To ensure heartworm disease prevention, observe your dog for one hour after administration. Readminister a dose if the dog vomits.

Trifexis's most common adverse reactions reported are vomiting, lethargy, decreased activity, itching, decreased appetite, and diarrhea. Other dog sensitivities could demonstrate redness on their skin, eyes, ears, etc.

We hope that the below FAQs can answer some of the reviewers' and your concerns.

  1. What do the Trifexis reviews say?

    Trifexis reviews demonstrate 4.5+ stars out of 5. Most reviewers say that Trifexis is the only flea and heartworm medication that they trust for their furry best friend.

    The few unsatisfied customers do have justified concerns: its high expense (#2), finding worms in their dog's stool (#7), its large size and it's bad taste (#5), and not seeing an immediate result (#7).

    Look above at potential side effects, such as lethargy, drunk-like behavior, or even itchiness. Contact your veterinarian for a check-up if having any concerns or questions about your dog's use of Trifexis.

  2. What is the Trifexis dosage?

    When you purchase Trifexis, know that your dog's weight affects the dosage that you choose. There are monthly chewable tablets for 5-10 lbs, 10.1-20 lbs, 20.1-40 lbs, 40.1-60 lbs, or 60.1-120 lbs.

    According to your dog's weight, the chosen Trifexis will provide the comparable dosage (i.e., the milligram amounts of the two active ingredients, spinosad and milbemycin oxime) as told to you by your veterinarian.

  3. Is Trifexis chewable?

    Trifexis comes in the form of monthly chewable tablets. Trifexis is most effective when put in the dog's food.

  4. Is Trifexis for puppies?

    Trifexis can be administered to puppies that are at least 8 weeks and 5 pounds.

  5. How long does it take for Trifexis to work?

    In a laboratory study of spinosad alone, Trifexis started to kill fleas within 30 minutes and killed 100% of the fleas within 4 hours before they could lay eggs. Trifexis also brings quick relief to your pet in terms of killing adult hookworms, roundworms, and whipworms in one go.

    If you find fleas on your dog after 30 days, it means that it is a new batch of fleas. If you see intestinal parasites or worms in your dog's stool, it means that the medication is working, because it is clearing out the system.

  6. Is Trifexis for cats?

    Trifexis was only made to be administered to dogs, and therefore Trifexis is not for cats.

    However, there are cat equivalents to Trifexis. For your household or outdoor kitty, look for Revolution Plus for Cats, which is a monthly solution that treats 6 parasites in 1 topical cream. Also, Capstar Flea Killer for Cats is an over-the-counter daily oral tablet for quick relief for your cat's.

Concluding Thoughts

The most important thing that you should know about Trifexis is its power to protect your dog from tiny parasites and the dangerous heartworm disease.

DISCLAIMER: Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition.

An effective and affordable alternative to Trifexis is Sentinel

Side Effects & Warnings

Adverse reactions to Trifexis include vomiting, itching, ear redness, skin redness and inflammation, loss of appetite, diarrhea, and lethargy. Use Trifexis with caution in dogs with epilepsy. Puppies less than 14 weeks old may excessively vomit. Consult your veterinarian in regard to pregnant or lactating dogs before giving them Trifexis. If your dog experiences any listed effects, contact your veterinarian immediately. Trifexis is not meant for any Collie breed dogs.

Do not use ivermectin in addition to Trifexis. Consult your veterinarian regarding the addition of any other medication, supplement, or vitamins.


Trifexis contains:

Spinosad, Milbemycin oxime


Dog must be tested by a veterinarian, and rid of worms, prior to taking Trifexis. Administer Trifexis orally according to prescribed dosage, based on weight.

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