Tri-Heart Plus

Tri-Heart Plus

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Product Description

Ultimate Guide to Tri-Heart Plus

Meet the Heart Protector from Parasites: Tri-Heart Plus!

Tri-Heart Plus is an FDA-approved, veterinarian-recommended medication that protects against life-threatening canine heartworm disease and treats and controls roundworms and hookworms.  Tri-Heart Plus is a monthly, beef-flavored chewable tablet that is safe to take year-round. Tri-Heart Plus ensures that your pup is in the best lovable condition!

How do the Tri-Heart Plus ingredients work?

Tri-Heart Plus is a medication with two active ingredients - Ivermectin and Pyrantel.

Ivermectin is a broad-spectrum, anti-parasitic agent that prevents heartworm disease and cures parasitic infections to help to improve your dog's quality of life. Ivermectin paralyzes the parasite through the insect's nervous system and eventually kills the parasite.

The second active ingredient, Pyrantel, is an anti-worm drug (i.e., anthelmintic) that is used to treat roundworm, hookworm, pinworm, and other worm infections.  It also works by paralyzing the parasite so that the body can remove them naturally in the stool.

How is Tri-Heart Plus administered?

Dogs must be tested for heartworm infection before starting a preventive program and before starting to use the medication.  Tri-Heart Plus for dogs is a beef-flavored chewable tablet administered orally once a month and protects your dog for the next 30 days.

Depending on the body weight of your dog, there are three different colored boxes provided with different micrograms of Ivermectin and milligrams of Pyrantel in every tablet.  See the dosage chart below:

Body Weight

Ivermectin (mcg)

Pyrantel (mg)

0 - 25 lbs.



26 - 50 lbs.



51 - 100 lbs.



What are the precautions of which you should be aware?

Test your dog for heartworm disease before using Tri-Heart Plus and before any heartworm prevention therapy. Already infected dogs need to be dewormed before administering Tri-Heart Plus.  

What are the potential side effects of which you should be aware?

Tri-Heart Plus's most common adverse reactions reported are vomiting, depression, depression, anorexia, ataxia (a degenerative neurological disease that causes bad body coordination), convulsions, mydriasis (pupil dilation), hypersalivation, and diarrhea.

Frequently Asked Questions
  1. What do the Tri-Heart Plus reviews say?

    Tri-Heart Plus reviews rate 4.5 out of 5 stars. Most reviewers say that Tri-Heart Plus is a highly effective product that they trust for all of their dogs' hearts.

  2. Which Tri-Heart Plus dosages available?

    The Tri-Heart Plus blue box is for 0 - 25 lbs. dogs, the green box is for Tri-Heart Plus 26 - 50 lbs., and the Tri-Heart Plus 51 - 100 lbs. is the brown box. The Tri-Heart Plus tablets come in 12-pack boxes.

  3. Is the product Tri-Heart Plus heartworm prevention for dogs?

    Tri-Heart Plus is a chewable heartworm medication that is an effective preventative for canine heartworm disease.

  4. Is Tri-Heart Plus for cats?

    No. Tri-Heart Plus is not approved for use for cats. Tri-Heart Plus was made to be an effective preventative for canine heartworm disease and to eliminate other internal parasites only.

  5. Does Tri-Heart Plus prevent fleas?

    No. Tri-Heart Plus tablets are labeled for heartworm prevention, roundworms, and hookworms. The medication is not to affect external parasites.

Concluding Thoughts

The most important thing that you should know about Tri-Heart Plus is its power to prevent, treat, and control for three internal parasites that threaten your furry best friend's heart health and quality of life.

DISCLAIMER: FDA law restricts Tri-Heart Plus to use by or on the order of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.  This informative article does not substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Tri-Heart Plus is a prescription medication for dogs ONLY.

Side Effects & Warnings

All dogs should be tested for heartworm infection before starting a preventive program. In a small percentage of ivermectin/ pyrantel treated dogs, digestive and neurological side effects may occur.


Tri Heart Plus contains Ivermectin and Pyrantel pamoate


Dogs must be tested for heartworm infection before starting a preventive program like Tri-Heart Plus.

Tri Heart Plus may be administered orally once a month, at the veterinarian prescribed dose. Most dogs will readily chew the medication, but if your dog is used to swallowing pills, break it up into smaller pieces. Make sure the dog consumes the entire dose.

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