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Product Description

Comprehensive Guide to Selegiline

Meet the Aged Behavioral Problem Manager: Selegiline!

Selegiline is a Monoamine Oxidase Inhibitor (MAOI) that manages behavioral problems associated with middle-aged and older dogs, such as Parkinson's disease, Canine Cognitive Dysfunction Syndrome (senility), and Cushing's Disease. Selegiline is a daily oral tablet for both dogs and cats.

How does Selegiline work?

As a monoamine oxidase inhibitor (MAOI), Selegiline helps in significantly enhancing the concentration of a nervous system messenger chemical known as dopamine, which is used to treat cognitive dysfunction (caused by aging), anxiety, and phobias in animals. Higher levels of dopamine stimulate brain receptors and cognitive processes.

Selegiline contains several ingredients - selegiline hydrochloride, citric acid, lactose monohydrate, maize starch, magnesium stearate, povidone, and talc. Selegiline Hydrochloride (HCL) is an antidepressant that treats Parkinson's disease and depression.

Maize starch in pet foods aids those pets that are suffering from corn allergy. Povidone is a topical cleanser that supports the healing of wounds and skin irritations. Magnesium stearate, povidone, and talc are natural additives. Citric acid is a common additive and a natural functional compound for pet health and wellness.

How is Selegiline administered?

Selegiline is a 5 mg tablet or capsule that is administered orally once a day with or without food. Dogs are usually given in the morning and cats in the evening.

The recommended starting dosage for treating Cushing's disease is .45 mg per pound which is taken in the morning. The recommended starting dosage for Canine C.D.S. is usually .20 to .45 mg per pound.

It may take one month to show significant improvement; however, if no improvement is seen in two months, increase the medication's dosage to .90 mg per pound. Consult your veterinarian for any specifics and adjustments for administration.

What are the potential side effects of which you should be aware?

Selegiline's common adverse reactions include vomiting, disorientation, aggression, hearing loss, decreased appetite, hair loss, trembling, or diarrhea. Overdose symptoms are hypersalivation, panting, or dehydration. Immediately, consult a veterinarian or emergency clinic if any above side effects or any allergic reactions occur.

What are the precautions of which you should be aware?

Be sure to tell your veterinarian about any medications, vitamins, or supplements that your pet is taking.

The following animals have not prescribed Selegiline:

  • Those that are allergic to it

  • Those that are pregnant or lactating

  • Those that have Cushing's disease

  • Those have a pituitary tumor

  • Those that are taking SSRI antidepressants, tricyclic antidepressants, narcotics, or other MAOIs

  • Those that have an adrenal gland-based Cushing's disease

  • Those that are aggressive pets

Frequently asked Questions
  1. What are the Selegiline brand names?

    Anipryl, Eldepryl, I-deprenyl, Selgian, and Zelapar.

  2. What are the Selegiline contraindications (drugs with negative interactions)?

    Some drugs that may negatively interact with Selegiline include antidepressants, other MAOIs, appetite suppressants, ADHD drugs, cold medication, nasal decongestants, stimulants, some supplements, some herbal products, and certain triptans used to treat migraines.

    This also includes apraclonidine, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, fentanyl, oxcarbazepine, tetrabenazine, and valbenazine.

  3. What do Selegiline reviews say?

    Selegine's reviews rate 5 out of 5 stars. Most reviewers say divided review - between it improves their pet's situation and that it's a miracle drug.

  4. How long does the medicine stay in the animal's system?

    The short-acting medication should stop working within the next 24 hours after administration, although effects can be longer in pets with liver or kidney disease.

Concluding Thoughts

The most important thing that you should know about Selegiline is that it treats behavioral problems and cognitive dysfunction, such as Parkinson's disease, Canine Cognitive Dysfunction Syndrome, and Cushing's Disease, caused by your pet's aging.

DISCLAIMER: FDA law restricts Selegiline only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427, if this is a suitable product for your pet and your home. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA-approved and/or EPA regulated when and as required by law.

Side Effects & Warnings

Not meant for dogs with aggression issues.

Possibly side effects include:

Decreased appetite, drooling, vomiting and diarrhea, fatigue, confusion, restlessness, hearing loss, trembling, itching, hair loss, anemia (pale gums). Repetitive behaviors (ex. walking in circles, obsessive interest in something). If your dog suffers an allergic reaction such as hives, swelling of lips, tongue or face or difficulty breathing seek immediate emergency veterinary medical attention and discontinue dosages. Other less serious side effects may occur such as nausea or upset stomach, diarrhea or headache. If these, or any other side effects seem unusualy or bothersome to your animal talk to your veterinarian.

Possible interactions may occur with ephedrine or other MAOI's. Discontinue selegiline at least 14 days prior to starting treatment with some narcotic pain killers (ex. Demerol), phenylpropanolamine, SSRI's (ex. fluoxetine) and tricyclic antidepressants (ex. amitriptyline). Some narcotic pain killers (ex. Demerol), phenypropanolamine, SSRI's (ex. fluoxetine) and tricyclic antidepressants (ex. amitriptyline) should not be used within 5 weeks of administering selegiline.

If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian.


selegiline hydrochloride, citric acid, lactose monohydrate, maize starch, magnesium stearate, povidone and talc.


Give your dog the recommended dosage (typically one pill) every morning.

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