Proin (Phenylpropanolamine)

Proin (Phenylpropanolamine)

Requires Rx

Free delivery


Every time a new member signs up, we will donate a FREE membership to a Best Friends adopted animal. Best Friends is America's largest animal sanctuary.

Get all these benefits with $99 annual membership


Our customers typically save close to $200/yr when purchasing preventatives as members of PetPlus.

PetPlus is a membership plan that gives you wholesale pricing on preventatives, supplements and speciality foods.
With Free Shipping always, no minimums.

Why Become A Member? Additional Ways To Save With PetPlus

Typical Annual Savings "For Your Pet

Typical Annual Cost $40 $190 $95 $112 $200
PetPlus Annual Cost $12 $110 $55 $68 $150
  Sample Annual PetPlus Savings $28 $80 $40 $44 $65
Typical Annual Cost
PetPlus Annual Cost
Sample Annual PetPlus Savings

We're Here to Help You Every Step of the Way

average savings

$242 / YR

Wholesale Prices on Pet Medication & Supplements
Free 24/7 Pet Help provided by whiskerDocs
Wholesale Prices on RX & Premium Foods and Treats
Convenient Medication Pickup Option
Free Delivery on Medication
Product Description

Ultimate Guide to Proin (Phenylpropanolamine)

Meet the Urinary Incontinence Controller: Proin!

Proin is a veterinarian-approved and FDA-approved pet medication that is used to control urinary incontinence. Proin is a chewable, oral tablet that can be taken every 12 hours to three times daily. Proin ensures aiding your pet's confidence in lowering their accidents at home.

How does Proin work?

Proin has its active ingredient in its name - phenylpropanolamine. So when the pet experiences urinary incontinence whether a puppy, a senior, or as a new distressing issue, they require a substance to treat their urologic issues, most likely bladder dysfunction or urethral sphincter incompetence.

The Proin (phenylpropanolamine) mechanism of action against pet urologic issues, as a supplemental adrenergic agent, is to activate the adrenal receptors (i.e., adrenaline equivalents are epinephrine and norepinephrine), which are the hormones needed to increase the dog's heart rate and improve blood flow.

This triggers vasoconstriction, the constriction of blood vessels, near their bladder muscles, and therefore strengthens the pet's urethral sphincter thereby preventing urine leakage.

How is Proin administered?

Proin is administered orally every 12 hours to three times a day. These liver-flavored chewable tablets can be used as dog treats or, most effectively, eaten with the dog's food.

The recommended dosage for dogs is .4 to .8 mg per lb. every 12 hours or three times daily. Other recommendations say that .91 mg/lb twice daily*. At the end of the day, it is obvious to always follow the exact recommendation of your veterinarian.

Proin bottles come in 25 mg, 50 mg, and 75 mg with 30 tablets per bottle. Proin tablets are scored down the middle to make it easy to split the tablets for a recommended dosage.

*For example, a 30 lb dog could take a 25 mg tablet twice daily.

What are the precautions of which you should be aware?

Notify your veterinarian of any medications, treatments, or vitamins your dog is taking, before administering Proin.

Keep away from dogs that are allergic to its ingredients. Keep away from pregnant or breeding pets. Keep away from dogs suffering from diabetes, glaucoma, enlarged prostate, hyperthyroidism, heart problems, or high blood pressure, and Proin worsens the conditions.

Proin is not for human use and ingestion. Keep out of reach of children.

What are the potential side effects of which you should be aware?

Proin's most common adverse reactions reported are anxiety, increased heart rate, high blood pressure, decreased appetite, polydipsia, vomiting, and hyperexcitability, if a recommended dosage doesn't maintain a pet's balanced phenylpropanolamine levels. Less common side effects are lethargy, pale gums, difficulty in urinating, and strokes.

Frequently Asked Questions
  1. What are the effects of the active ingredient Phenylpropanolamine?

    Phenylpropanolamine is an adrenergic agent that connects to adrenaline receptors resulting in vasoconstriction, the constriction of blood vessels, that causes the tightening of bladder muscles and strengthening the urethral sphincter to aid in urinary incontinence. Phenylpropanolamine hydrochloride is the drug's salt form.

  2. What are the reasons that dogs and cats take Proin?

    To treat urinary incontinence by maintaining balanced phenylpropanolamine levels.

  3. What are the most common Proin side effects?

    Proin's side effects that are reported are anxiety, irritability, increased heart rate, high blood pressure, loss of appetite, and hyperexcitability if a recommended dosage doesn't maintain balanced phenylpropanolamine levels. Less common side effects can be lethargy, pale gums, seizures, difficulty in urinating, or even strokes.

  4. What is the Proin dosage?

    Proin tablets come in 25 mg, 50 mg, and 75 mg tablets. Dogs take .4 to .8 mg per pound of body weight every 12 hours to three times daily. If urinary incontinence occurs at night, give the largest dose before going to sleep. This medication will take effect quickly, in about 1 to 2 hours, and clinical improvement should follow.

  5. What do the Proin reviews say?

    Proin (phenylpropanolamine) reviews rate 5 out of 5 stars. Reviewers say that Proin is an effective urinary incontinence medication from puppies to senior dogs and that liver-flavored oral and chewable Proin tablets are easy to administer because they are tastier than other pet medications.

Concluding Thoughts

The most important thing that you should know about Proin (Phenylpropanolamine) is its effective power to aid in puppy and senior's urinary incontinence and then their confidence and then improving their quality of life!

DISCLAIMER: FDA law restricts Proin (Phenylpropanolamine) only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian if it's a good idea to treat all of the animals in your household to control a home flea infestation.

Side Effects & Warnings

Keep out of reach of children.

Do not give with ephedrine or epinephrine, or within two weeks of using a MAOi, such as Anipryl, selegiline or a Preventic Collar. Proin may cause restlessness and hyperactivity, pale gums, difficulty urinating, irritability, hypertension, and decreased appetite. Hypertension risk increases if Proin is given concurrently with non-steroidal anti-inflammatory drugs (NSAIDs), or with reserpine, tricyclic antidepressants, amitraz (the active ingredient of the Preventic tick control collar and canine Promeris, a flea control product), or ganglionic blocking agents. Conditions such as glaucoma, prostatic hypertrophy, hypertension, hyperthyroidism, diabetes mellitus, and cardiovascular disorders, may worsen.

Side effects may worsen if used in conjunction with other sympathomimetic drugs such as ephedrine or epinephrine. Notify your veterinarian of any medications, treatments or vitamins your dog is taking, prior to administering Proin.



Phenylpropanolamine is an adrenergic agent effective in the treatment of urinary incontinence in animals. This extra-label medication is fit to be used only in dogs. Phenylpropanolamine works by increasing the sphincter tone of urethra, which tightens the bladder sphincter muscles thereby preventing urine leakage.


Proin is available in 25 mg, 50 mg, and 75 mg chewable tablets. The dosage of Proin generally depends on the bodyweight of the animal. However, a dose of 12.5 mg to 50 mg can be administered three times daily, depending on weight. The usual dose of Proin in dogs is 0.4-0.8 mg/pound every 12 hours. Overdosage can bring about symptoms of high blood pressure, increased heart rate, seizures, or coma. Do not increase or reduce the dosage without a veterinary prescription.

Administer Proin chewable tablets, to the exact specifications of your veterinarian, and with food.

Pet Weight Dosage
Dogs All Weights Tablets: The usual dose for dogs is 0.4-0.8mg/pound every 12 hours. Drops: 0.4-0.8mg/pound every 12 hours.

Need Help? Call 1-866-893-0306