Proin Extended Release

Proin Extended Release

Requires Rx

Free delivery


Every time a new member signs up, we will donate a FREE membership to a Best Friends adopted animal. Best Friends is America's largest animal sanctuary.

Get all these benefits with $139.95 annual membership


Our customers typically save close to $200/yr when purchasing preventatives as members of PetPlus.

PetPlus is a membership plan that gives you wholesale pricing on preventatives, supplements and speciality foods.
With Free Shipping always, no minimums.

Why Become A Member? Additional Ways To Save With PetPlus

Typical Annual Savings "For Your Pet

Typical Annual Cost $40 $190 $95 $112 $200
PetPlus Annual Cost $12 $110 $55 $68 $150
  Sample Annual PetPlus Savings $28 $80 $40 $44 $65
Typical Annual Cost
PetPlus Annual Cost
Sample Annual PetPlus Savings

We're Here to Help You Every Step of the Way

average savings

$242 / YR

Wholesale Prices on Pet Medication & Supplements
Free 24/7 Pet Help provided by whiskerDocs
Wholesale Prices on RX & Premium Foods and Treats
Convenient Medication Pickup Option
Free Delivery on Medication
Product Description

Proin Extended-Release for dogs with urinary incontinence

An increasing number of pet owners are facing the heart-wrenching problem of incontinence in their dogs, which causes accidents in the house and can lead to serious health problems if not treated quickly and effectively. Proin Extended-Release is one treatment option that your veterinarian may recommend to help ease your dog's symptoms of incontinence. Here's everything you need to know about Proin Extended-Release, including how it works, what it does, side effects, and more.

What is Proin Extended-Release?

Proin ER is a prescription medication used to treat urethral sphincter hypotonus in dogs. This condition occurs when there is muscle weakness in one of your dog's urethral sphincters, causing urine to leak out unexpectedly. The use of Proin ER allows these muscles to function properly again.

How does Proin Extended-Release work?

Proin extended-release is a prescription medication used to help control urinary incontinence in dogs due to urethral sphincter hypotonus, a weakening of the muscle in the urethra. The medication works by relaxing smooth muscles and stimulating the contraction of excitable tissues. It works by relaxing bladder muscles and stimulating the contraction of pelvic floor muscles that are normally involved in controlling urination.

Side Effects & Warnings

Proin ER may mask signs of incontinence due to urinary tract infection. Proin ER is not effective in dogs with incontinence due to neurologic disease or malformations. Proin ER may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension. Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias. A laboratory study on human blood revealed that phenylpropanolamine (PPA) used in conjunction with aspirin may potentiate decreased platelet aggregation. Proin ER may cause increased thirst; therefore, provide dogs with ample fresh water. The safe use of Proin ER has not been evaluated in dogs that are intended for breeding, or that are pregnant or lactating.


Phenylpropanolamine hydrochloride


Administer Proin chewable tablets, to the exact specifications of your veterinarian.

Need Help? Call 1-866-893-0306