Proin Extended Release

Proin Extended Release

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Product Description

Proin Extended-Release for dogs with urinary incontinence

An increasing number of pet owners are facing the heart-wrenching problem of incontinence in their dogs, which causes accidents in the house and can lead to serious health problems if not treated quickly and effectively. Proin Extended-Release is one treatment option your veterinarian may recommend to help ease your dog's incontinence symptoms. Here's everything you need to know about Proin Extended-Release, including how it works, what it does, side effects, and more.

What is Proin Extended-Release?

Proin ER is a prescription medication used to treat urethral sphincter hypotonus in dogs. This condition occurs when there is muscle weakness in one of your dog's urethral sphincters, causing urine to leak out unexpectedly. The use of Proin ER allows these muscles to function properly again.

The drug is formulated in chewable tablets, commonly referred to as Proin chewable tablets, for easy administration to dogs. This formulation is advantageous, especially in cases where traditional pill administration may be challenging.

How does Proin Extended-Release work?

Proin extended-release is a prescription medication used to help control urinary incontinence in dogs due to urethral sphincter hypotonus, a weakening of the muscle in the urethra. The medication works by relaxing smooth muscles and stimulating the contraction of excitable tissues. It works by relaxing bladder muscles and stimulating the contraction of pelvic floor muscles that are normally involved in controlling urination.

Proin Extended Release (Proin ER) is a veterinary medication designed to address urinary incontinence in dogs, particularly in spayed females. The active pharmaceutical ingredient in Proin ER is phenylpropanolamine hydrochloride, which acts as an alpha-1 adrenergic agonist. This means that it stimulates alpha-1 adrenergic receptors, resulting in smooth muscle contraction, particularly in the urethral sphincter. The increased tone in the urethral smooth muscle helps to prevent urine leakage and control urinary incontinence.

However, the use of Proin ER requires careful consideration of the dog's overall health. Dogs with pre-existing heart disease may be more susceptible to the sympathomimetic effects of the drug, potentially leading to increased heart rate and exacerbation of cardiovascular conditions. Similarly, caution is warranted in dogs with elevated blood pressure.

Proin ER metabolism involves hepatic pathways, making monitoring dogs with liver disease crucial for any signs of hepatic dysfunction. The drug's impact on liver enzymes should be regularly assessed to ensure its safety and efficacy. Additionally, dogs with kidney insufficiency require close monitoring, as alterations in kidney function may occur.

Adverse events associated with Proin ER can manifest as unusual signs in dogs, such as behavioral changes, increased heart rate, or respiratory distress. Pet owners must be vigilant and promptly report any adverse events to the veterinarian.

Urine retention is a potential complication of Proin ER use, and prolonged retention may lead to kidney failure. Pet owners should be educated on the signs of kidney failure, including altered urination patterns, increased thirst, and lethargy, and seek veterinary attention if observed.

Regular veterinary follow-ups are advised to monitor liver enzyme levels and overall health. If liver enzyme elevations occur, discontinuation of Proin ER may be necessary, and alternative treatments may be considered.

Side Effects & Warnings

Proin ER may mask signs of incontinence due to urinary tract infection. Proin ER is not effective in dogs with incontinence due to neurologic disease or malformations. Proin ER may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension. Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias. A laboratory study on human blood revealed that phenylpropanolamine (PPA) used in conjunction with aspirin may potentiate decreased platelet aggregation. Proin ER may cause increased thirst; therefore, provide dogs with ample fresh water. The safe use of Proin ER has not been evaluated in dogs that are intended for breeding, or that are pregnant or lactating.


Phenylpropanolamine hydrochloride


Administer Proin chewable tablets, to the exact specifications of your veterinarian.

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