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An anticonvulsant that reduces the frequency and severity of seizures and controls epilepsy.When Primidone is ingested, it’s converted to phenobarbital which is an anticonvulsant. It works by decreasing nerve impulses in the nervous system, which helps to reduce seizures.
Generally used for dogs only.
Side Effects & Warnings
If your pet develops any of the following serious side effects, stop giving primidone and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue, face, or hives); a rash; worsening of seizures; fever. Other less serious side effects may occur. Continue to give primidone and talk to your veterinarian if your pet experiences dizziness, poor coordination, or drowsiness; blurred vision; irregular back and forth movements of the eyes; or nausea and vomiting
Possible interactions: Acetazolamide (Diamox), carbamazepine (Tegretol), ethosuximide (Zarontin), and methsuximide (Celontin) may decrease the effects of primidone and require a higher primidone dose. Phenytoin (Dilantin), ethotoin (Peganone), mephenytoin (Mesantoin), and isoniazid may increase the effects of primidone and require a lower primidone dose. Carbamezepine (Tegretol) blood levels may increase when given with primidone. The carbamazepine dose may need to be adjusted lower. CNS depressants, valproic acid and chloramphenicol may increase the effect of primidone. Primidone may decrease the effect of coumadin, corticosteroids (such as prednisone), beta blockers (such as atenolol), theophylline and metronidazole. Use with caution when giving primidone with furosemide, griseofulvin or rifampin.
Keep out of the reach of children and other pets.
Use as directed by your veterinarian.
Dogs (all weights) The usual dose in dogs is 2.3-6.8 mg per pound of pet’s body weight per day in 2 or 3 divided doses. Primidone can be given with food. Allow plenty of water for your pet to drink.
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