Piroxicam

Piroxicam

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Product Description

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in veterinary medicine. Initially developed for human use, its efficacy and safety profile have led to its adoption in veterinary practice. Veterinarians often prescribe piroxicam for various conditions, including cancer treatment in animals.

  • Medical Applications:One of the most common uses of piroxicam in veterinary medicine is its application as an anti-tumor medication. It has shown promise in treating various types of cancers in animals, including bladder transitional cell carcinoma, squamous cell carcinoma, mammary adenocarcinoma, inflammatory mammary carcinoma, and transmissible venereal tumors. Additionally, piroxicam is used in managing degenerative joint disease in aging pets, providing relief from pain and inflammation associated with this condition.

  • Administration and Dosage:Piroxicam is typically administered orally, often in capsule form. However, its use may be off-label or extra-label in certain cases, as determined by the prescribing veterinarian. It's crucial to follow the prescribed dosage and administration instructions carefully to ensure its effectiveness and minimize the risk of adverse effects.

  • Potential Side Effects:Common side effects can include stomach upset, vomiting, diarrhea, or poor appetite. More severe side effects can include gastrointestinal ulceration and bleeding, kidney damage, central nervous system effects, elevated liver enzymes, decreased red blood cell counts, and impaired heart function.

  • Considerations for Special Cases:Special attention is required when administering piroxicam to certain groups of animals. Pregnant or nursing pets should not receive piroxicam due to potential risks to offspring. Aging pets may also require careful monitoring due to their increased susceptibility to adverse effects.

  • Drug Interactions:Piroxicam can interact with a variety of other medications, including aminoglycosides, anticoagulants, aspirin, bisphosphonates, cisplatin, corticosteroids, cyclosporine, digoxin, diuretics, highly protein-bound drugs, methotrexate, SNRIs and SSRIs, tacrolimus, and tricyclic antidepressants. These interactions can have adverse effects or reduce the efficacy of either medication, which necessitates close monitoring and potential dosage adjustments.

  • Monitoring and Storage:Regular monitoring is essential when administering piroxicam to animals. This may involve periodic blood tests to assess liver enzymes, kidney function, and red blood cell counts. Piroxicam should be stored at room temperature and seek emergency veterinary care immediately in case of overdose or adverse reactions.

Piroxicam is a valuable medication in veterinary oncology and pain management. However, its use requires careful consideration of potential side effects, drug interactions, and monitoring protocols to ensure the safety and well-being of animals undergoing treatment.

Side Effects & Warnings

When administering Piroxicam, contact your veterinarian if your pet shows signs of depression, an increase in drinking, jaundice, dizziness, seizures, behavior changes, lethargy, swelling, shedding, itching, constipation, or hot spots. In some cases, Piroxicam can cause stomach ulceration. Signs of this include loss of appetite, diarrhea, vomiting, and bloody or black stools.

Do not use Piroxicam in pets with kidney or liver disease, bleeding disorders, gastric ulcers, or high blood pressure. Use with caution in cats and pets with severe heart disease.

Negative interactions can occur with ACE-inhibitors such as enalapril, benazepril, and quinapril. Piroxicam may interact with other drugs like phenylbutazone, heparin, aspirin, corticosteroids, methotrexate, flunixin, diazepam, propranolol, and warfarin.

Ingredients

Piroxicam is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly used for managing pain and inflammation in dogs. The action mechanism of Piroxicam is to hinder the secretion of prostaglandins, thereby bringing relief from fever, pain and inflammation. It could also be combined with other drugs in the treatment of transitional cell carcinoma- a type of bladder cancer in dogs.


Clinical results have proved that this drug is well tolerated by dogs, even though side effects might occur in rare cases. Stomach and intestinal ulcers, bleeding, dark stools, peritonitis, vomiting etc., are some of the common side effects. A few of these could be life threatening as well. Piroxicam can hamper the smooth functioning of kidneys which might lead to papillary necrosis. Piroxicam could also damage the natural blood clotting mechanism, thereby increasing the risks of bleeding.

Desist from using Piroxicam in animals that are allergic to this drug, and in those with a noted history of bleeding, intestinal inflammation and high blood pressure. Use extreme caution while administering this medication in pets with heart ailments. Some medicines such as diuretics or ACE-inhibitors could have serious interactions with Piroxicam. So, make sure to verify that the medications administered to the pet do not belong to any of these groups. Piroxicam, when used along with corticosteroids is found to enhance the risks of ulcers.

Directions

Piroxicam is available in 10 mg and 20 mg capsules. The dosage might differ according to the condition for which it is used, and the response to the treatment. Normally for anti-inflammatory effect, piroxicam is dosed at 0.15 mg per pound (0.3 mg/kg) every 48 hours, while a daily dose of 0.15 mg per pound (0.3 mg/kg) might be required to manage transitional cell carcinoma.

Piroxicam is a prescription drug. Administer Piroxicam orally per instruction by your veterinarian.

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