NexGard® COMBO topical solution for Cats

NexGard® COMBO topical solution for Cats

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Product Description

NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) for Cats kills fleas and ticks, prevents heartworm disease, and treats and controls hookworms, roundworms and tapeworms. NexGard® COMBO topical solution is parasite protection for cats from the maker of vet-recommended1 NexGard® (afoxolaner) and HEARTGARD® Plus (ivermectin/pyrantel).

All cats need parasite protection, even indoor cats. Applied monthly, NexGard® COMBO is designed to deliver parasite protection to your cat year-round with an easy-to-use applicator. And it's the first and only broad-spectrum solution that treats and kills tapeworms.

NexGard® COMBO topical solution is one-and-done monthly protection formulated specifically for cats. It is safe and approved for cats and kittens as young as 8 weeks old, weighing 1.8 pounds or more.


NexGard® COMBO is for topical use only in cats. Use with caution in cats with a history of seizures or neurologic disorders. For more information, contact your veterinarian or refer to the full prescribing information.

1. Data on file at Boehringer Ingelheim

Side Effects & Warnings

The most frequently reported adverse reactions include vomiting, application site reactions, and anorexia.


Active Ingredients: esafoxolaner, eprinomectin and praziquantel


NexGard® COMBO is dosed at a minimum of 0.055 mL/lb. (0.12 mL/kg), which delivers a minimum dose of 0.65 mg/lb. (1.44 mg/kg) esafoxolaner, 0.22 mg/lb. (0.48 mg/kg) eprinomectin, and 4.53 mg/lb. (9.98 mg/kg) praziquantel. Administer the entire contents of a NexGard® COMBO unit applicator topically once a month. For heartworm disease prevention, apply once monthly for at least three months after last exposure to mosquitoes.

  1. Use scissors to cut the blister along the dotted line.
  2. Then pull the lid away.
  3. Remove the applicator from the package and hold it upright. Pull back the plunger slightly.
  4. Twist and pull off the cap.
  5. Part the hair on the midline of the neck, between the base of the skull and the shoulder blades until the skin is visible. Place the tip of the applicator on the skin and apply the entire contents directly onto the skin in one spot. The product should be applied to dry skin on an area where the cat cannot lick it off. If the weight of the cat requires a second application, apply the contents in the same manner as described above in the same location.
  6. Wash hands after use with soap and water.

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