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Our customers typically save close to $200/yr when purchasing preventatives as members of PetPlus.

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Typical Annual Savings "For Your Pet

Typical Annual Cost $40 $190 $95 $112 $200
PetPlus Annual Cost $12 $110 $55 $68 $150
  Sample Annual PetPlus Savings $28 $80 $40 $44 $65
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Product Description

Doxepin is an orally administered, prescription medication that treats behavioral disorders in dogs and cats, including depression, noise phobia, and obsessive-compulsive disorder. It may also be prescribed for skin conditions caused by anxiety. In addition, Doxepin is a potent antihistamine.

Doxepin is the Generic Alternative to Sinequan.

Side Effects & Warnings

Side effects include low blood pressure, high blood pressure, rapid heart rate, constipation, dry mouth, and blue-green urine. Doxepin should not be used in animals with known hypersensitivity or allergy to the drug, glaucoma or problems associated with urinary retention. Use with caution in seizure-prone animals.

Notify your veterinarian of other medications that your pet is taking. Drug interactions occur with monoamine oxidase inhibitors, thyroid medications, atropine sedatives, antihistamines, norepinephrine and phenytoin. The following drugs may increase the effects of doxepin: cimetidine (Tagamet) estrogens fluoxetine (Prozac) some sedatives enalapril verapamil and ranitidine (Zantac).


Doxepin Hydrochloride


Follow exact directions prescribed by veterinarian.

The usual dosage is 0.25 to 0.5 mg per pound (0.5 to 1 mg/kg) orally, every 12 hours, or 1.5 to 2.5 mg per pound (3 to 5 mg/kg) orally every 8 to 12 hours.

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