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Product Description

Dexamethasone, a glucocorticoid steroid medication, treats various inflammatory conditions, adrenal gland diseases, and immune-mediated disorders in pets. Its multifaceted applications extend to diagnosing Cushing's disease and managing various ailments across animal species.

Pets ranging from cats, dogs, and small mammals to large animals benefit from dexamethasone's therapeutic effects in off-label or extra-label applications, indicating its versatility and efficacy in managing diverse health concerns.

  • Forms and Administration -Apart from the tablet form sold here, dexamethasone is also available in liquids, injections, aerosols, and topical eye medications, offering flexibility in administration. Whether administered orally, via injection, or topically, meticulous measurement and adherence to dosage instructions are imperative for optimal outcomes. It's noteworthy that dexamethasone administration may require caution when combined with NSAIDs.

  • Onset and Duration of Action -With onset of action typically ranging from 1 to 2 hours, dexamethasone provides relatively rapid relief from symptoms. However, discontinuing the medication abruptly after two weeks may lead to adverse effects, emphasizing the importance of gradual tapering or follow-up treatment plans.

  • Potential Side Effects and Risks -While dexamethasone effectively alleviates inflammation, it's not without potential side effects. Common side effects include increased drinking, urination, appetite, dull/dry haircoat, weight gain, muscle weakness, vomiting, and diarrhea. Serious side effects such as stomach or intestinal ulcers and bleeding, pancreatitis, diabetes mellitus, and behavior changes necessitate prompt veterinary attention.

  • Monitoring and Cautionary Measures -Monitoring pets undergoing dexamethasone therapy involves regular assessments of weight, appetite, electrolytes, blood proteins, blood sugar levels, signs of swelling, and growth and development. Caution should be exercised in pets with underlying conditions such as kidney disease, heart disease, bacterial or fungal infections, and in pregnant or lactating animals.

Awareness of potential drug interactions and proper storage conditions (room temperature, away from moisture and light) are crucial for maintaining the medication's efficacy and safety profile.

In the event of an overdose or adverse reactions, swift action is necessary. Pet owners should contact their veterinary office or emergency facility promptly for appropriate guidance and intervention.

Side Effects & Warnings

Since this drug affects the immune system of the recipient, certain diseases can end up being exacerbated by this treatment. Pets with a fungal disease, or viremia, should never be put on dexamethasone. Due to teratogenic effects of the drug, pregnant pets should only take dexamethasone if the benefits greatly outweigh the inherent risk to the fetus. Pets that have been taking dexamethasone long term, or in high doses, should be tapered off the drug slowly. Patients with congestive heart failure, diabetes, or osteoporosis should take dexamethasone with caution. Unless it is an emergency, pets with kidney disease, GI ulcers, or hyperadrenocorticism should not take dexamethasone. Dexamethasone should never be taken with other corticosteroids, NSAIDs, or immunosuppressants, as this might exacerbate the potential for negative side effects. Taking antacids may reduce the rate at which dexamethasone is absorbed. Patients with myasthenia gravis taking anticholinesterase and dexamethasone might suffer from profound muscle weakness. Anticoagulants may be increased or decreased in effectivity. Dexamethasone decreases the effects of bacteriostatic antibiotics. Taking with estrogen agents will likely potentiate the effects of dexamethasone. Macrolide antibiotics increase or prolong the effects of dexamethasone. Potassium depleting diuretics and Amphotericin B will likely cause hypokalemia. Thanks to the diminished immune response caused by dexamethasone, vaccinationsc should not be given to patients taking the treatment. Taking aspirin or acetylsalicylic acid might reduce salicylate levels. Taking cyclophosphamide will decrease the rate at which it (cyclophosphamide) can be metabolized. Same with cyclosporine. Taking digoxin might cause hypokalemia and digitalis, with an increased risk of digitalis toxicity. Dexamethasone might increase the required amount of insulin needed in diabetic patients. Ketoconazole might increase or prolong the glucocorticoid activity. Taking with mitotane might alter the recipients metabolism, and phenobarbital, phenytoin sodium, and rifampin will all have effects on the bodies ability to metabolize glucocorticoids, like dexamethasone.

May retard growth to young animals. Can cause dull coat, weight gain, panting, vomiting, diarrhea, elevated liver enzymes, pancreatitis, gastrointestinal ulcers, depression, lethargy and viciousness.

Do not stop using this medication suddenly, especially if it has been used for several weeks or more. The dose may need to be reduced over several days to prevent side effects.



Dexamethasone is a powerful anti-inflammatory, immunosuppressive drug that helps relieve pain caused by inflammation, whether it be in the joints thanks to arthritis, or a rash caused by allergies. Many conditions are the result of the body overreacting to a perceived threat (i.e., allergens) and over producing antibodies, which cause swelling. By suppressing the immune response, along with actively bringing down the swelling of affected areas, dexamethasone is able to effectively treat diseases like rheumatoid arthritis, systemic lupus, various allergies, asthma, dermatologic disease, hematologic disorders, neoplasia, nervous system disease, general inflammation, inflammatory bowel disease, and nephrotic syndrome.


Follow directions as given by your veterinarian.

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