Cyclosporine (Modified)

Cyclosporine (Modified)

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Product Description

Cyclosporine Capsules, USP (Modified), mark a significant milestone in veterinary medicine, offering a sophisticated and effective solution for managing skin infections and allergies in dogs and cats. These capsules are designed for oral administration and provide a less invasive and more accessible alternative to traditional injectable treatments.

Composition and Mechanism of Action

The active ingredient in these capsules is Cyclosporine, a potent immunosuppressive agent adapted for veterinary use. Its mechanism of action involves selectively inhibiting the activation of T-lymphocytes, key immune cells involved in inflammatory responses. By modulating the immune system at the cellular level, Cyclosporine addresses immune-mediated disorders, including canine atopic dermatitis and chronic mild inflammatory diseases in pets.

Cyclosporine Pharmacokinetics and Metabolism

The modified formulation ensures optimal absorption and distribution of Cyclosporine, leading to consistent therapeutic blood concentrations. Metabolism primarily occurs in the liver of dogs and cats, allowing for precise control over the drug's effects. Understanding the pharmacokinetics of Cyclosporine is crucial for tailoring treatment plans and providing veterinarians with the necessary tools to achieve therapeutic efficacy while minimizing potential side effects.

Clinical Efficacy and Specific Applications

Cyclosporine Capsules demonstrate clinical efficacy in managing various conditions prevalent in pets, including mild inflammatory bowel disease, urinary tract infections, and immune-mediated diseases like chronic hepatitis. By specifically targeting immune cells involved in the inflammatory cascade, Cyclosporine proves to be a versatile and comprehensive solution for addressing a spectrum of immune-mediated conditions in companion animals.

Less Invasive Option with Oral Administration

The oral administration of Cyclosporine Capsules presents a less invasive alternative to injectable treatments, ensuring ease of compliance for both pets and their caretakers. The convenience of oral administration fosters a stress-free experience, contributing to improved treatment adherencea critical factor in achieving long-term therapeutic success in veterinary care.

Optimal Cyclosporine Concentrations and Pharmacokinetics

Maintaining optimal blood concentrations of Cyclosporine is crucial for therapeutic effectiveness. The modified formulation and minimal renal excretion contribute to a controlled release of the drug, reducing the risk of fluctuations in blood levels. This precision in pharmacokinetics enhances the safety profile of Cyclosporine, addressing concerns related to potential organ toxicity in pets.

Individualized Treatment through Adjusting Drug Doses

Cyclosporine therapy for pets allows for individualized treatment plans by adjusting drug doses based on the specific needs of each patient. This tailored approach is particularly beneficial in chronic conditions, where adjusting the Cyclosporine dose ensures sustained efficacy while minimizing the risk of adverse effects. Dosing intervals can be personalized to accommodate the unique requirements of each pet, enhancing the overall success of the treatment.

Cyclosporine Capsules, USP (Modified), offer advanced veterinary care for canine and feline skin conditions, providing a less invasive and tailored solution for pets facing immune-mediated challenges. The formulation's adaptability and precise pharmacokinetics position these capsules as a valuable tool for veterinarians striving to achieve optimal therapeutic outcomes in companion animals.

Side Effects & Warnings

Please consult your veterinarian for side effects or any drug interactions.

Ingredients

Active ingredient:
Cyclosporine USP - 25, 50, or 100 mg Other ingredients:
Dehydrated Alcohol 18.6%, dl-alpha-tocopherol, FD&C blue #2 aluminum lake, ferric oxide (yellow), gelatin, glycine, glycerol 85%, polyoxyl 40 hydrogenated castor oil, polyglycerol (3) oleate, polyglycerol (10) oleate, sorbitol solution, titanium dioxide

Directions

Dogs/Puppies: (6 months and older over 4 lbs.)

Give 2.5mg per pound of body weight. The medication is usually given once a day to start until satisfactory improvement is seen, usually 4-8 weeks. The medication can then be given every other day until the clinical signs of atopic dermatitis are satisfactorily controlled, then the medication can be given every 3 or 4 days. Always give 1 hour before or 2 hours after a meal. Allow plenty of water for the pet to drink.

Cats/Kittens:(6 months and older over 4 lbs.)

Give 2.3-3.1mg per pound of body weight. The medication is usually given once a day to start until satisfactory improvement is seen, usually 4-8 weeks. The medication can then be given every other day until the clinical signs of atopic dermatitis are satisfactorily controlled, then the medication can be given every 3 or 4 days. Always give 1 hour before or 2 hours after a meal. Allow plenty of water for the pet to drink

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