Requires Rx

Free delivery


Every time a new member signs up, we will donate a FREE membership to a Best Friends adopted animal. Best Friends is America's largest animal sanctuary.

Get all these benefits with $139.95 annual membership


Our customers typically save close to $200/yr when purchasing preventatives as members of PetPlus.

PetPlus is a membership plan that gives you wholesale pricing on preventatives, supplements and speciality foods.
With Free Shipping always, no minimums.

Why Become A Member? Additional Ways To Save With PetPlus

Typical Annual Savings "For Your Pet

Typical Annual Cost $40 $190 $95 $112 $200
PetPlus Annual Cost $12 $110 $55 $68 $150
  Sample Annual PetPlus Savings $28 $80 $40 $44 $65
Typical Annual Cost
PetPlus Annual Cost
Sample Annual PetPlus Savings

We're Here to Help You Every Step of the Way

average savings

$242 / YR

Wholesale Prices on Pet Medication & Supplements
Free 24/7 Pet Help provided by whiskerDocs
Wholesale Prices on RX & Premium Foods and Treats
Convenient Medication Pickup Option
Free Delivery on Medication
Product Description

Ultimate Guide to Clomicalm

Meet the Canine Behavioral Conditioner: Clomicalm!

Clomicalm is an FDA-approved, veterinarian-recommended, prescription anti-depressant for dogs. Clomicalm is intended to treat separation anxiety, obsessive compulsive disorder (OCD), and other undesirable behavioral conditions in dogs. Use Clomicalm as a behavior modification tool to calm your dog in stressful situations.

How does Clomicalm work?

Clomicalm is a medication with one active ingredient - Clomipramine Hydrochloride.

Clomipramine Hydrochloride is a tricyclic antidepressant that works by restoring the balance of certain natural substances in the brain, including the happy chemical or feel good hormone serotonin. Clomipramine for dogs is the first FDA-approved generic substance that treats separation anxiety and any behavioral condition in dogs.

The prescription drug Clomicalm, a generic alternative for Anafranil, eliminates certain undesirable behavioral issues in dogs, including separation anxiety, OCD, excessive barking, aggressive or destructive behavior, and eliminating (urination or defecation) at inappropriate times. Most importantly, Clomicalm aids your dog in stressful situations.

How is Clomicalm administered?

Clomicalm is administered twice daily with food and lots of water. Your licensed veterinarian will prescribe the exact dosage and other specifications prescribed by your veterinarian. The usual dosage is with one to two mg per pound. Clomicalm are oral, beef flavored tablets and capsules of the active ingredient Clomipramine Hydrochloride.

The tablets come in 20 mg (blue), 40 mg (purple), and Clomicalm 80 mg (green) of Clomipramine Hydrochloride, and the dog is administered which tablet depending on their bodyweight. See the dosage chart below.

Body Weight

20 mg

40 mg

80 mg

11 - 22 lbs.


22.1 - 44 lbs.


44.1 - 88 lbs.


88.1 - 176 lbs.


What are Clomicalm side effects of which you should be aware?

Clomicalm may cause drowsiness.

Stop giving the medication Clomicalm and contact your vet if the pet experiences difficulty breathing, hives, irregular heartbeat, difficulty urinating, seizures, fever with increased panting, muscle stiffness or weakness, or swelling of the lips, tongue, or face.

Frequently Asked Questions 

What is Clomicalm used for in dogs?

Clomicalm is used to calm dogs that are feeling stressed due to some reason. It is somewhat of a behavior modification tool that can help your pet dog calm down.

Clomicalm tablets are used to treat separation anxiety in dogs. This particular medication is also used to treat behavior disorders in dogs. Be it anxiety-related, or destructive behavior in general, Clomicalm tablets can help your dog regain composure and calmness.

What does Clomicalm do for a dog?

Clomicalm relieves anxiety in dogs by restoring hormonal balance in their brains.

Clomipramine hydrochloride is a key component in Clomicalm. The name Clomicalm comes from the words clomipramine and calm meaning that it is a medicine for calming down dogs. Clomipramine hydrochloride is an antidepressant that helps promote the secretion of serotonin in the brain. This serotonin is a happy or feel-good chemical. It helps to get rid of the anxiety and calm your dog.

Clomicalm does the following things for your dog

  • Helps get rid of undesirable behavioral problems or characteristics like OCD or separation anxiety
  • Stops them from barking excessively
  • Makes them less aggressive
  • Calms them down whenever they are stressed

How long does it take for Clomicalm to work in dogs?

It can take almost eight weeks to understand whether or not Clomicalm is working for your dogs.

The impact of some medications cannot be understood instantaneously. Clomicalm is one of those medications. Unlike painkillers, you cannot see them at work right away. It needs a few weeks before you can determine whether or not your dog's anxiety or stress-related problems have been solved or not.

Can I use Clomicalm for a dog being scared of thunder?

Yes, you can use Clomicalm for a dog that is scared of thunder or fireworks.

Dogs being afraid of loud noises is a natural thing. Loud noises trigger their nervous system, and they end up feeling anxious or afraid. So to tackle this anxiety, you have to administer the Clomicalm tablets to your dogs. That way, they can remain calm even in stressful situations like a thunderstorm.

Apart from the medicine, you also need to ensure the safety of your dog during a storm. When the rumbling of the thunder grows stronger, try to suppress it with sounds from the TV or music.

Is Clomicalm the same as Prozac?

Yes, Clomicalm is the same as Prozac.

Prozac is used to treat anxiety. It does so by making sure that the brain does not reabsorb the naturally produced serotonin. As a result, the serotonin stays and ensures that the individual is in a good mood. Prozac is somewhat of a mood regulator as it helps maintain a serotonin balance in the brain, which in turn results in a less anxious mind.

Clomicalm does the same thing, except it enables the secretion of serotonin to maintain balance.

Does Clomicalm cause drowsiness?

Yes, Clomicalm does cause drowsiness. It is one of the few side effects this prescription medication has on dogs.

It is natural for prescription drugs to have side effects. Clomicalm is not an exception to this rule. It too, like many other dog medications, has certain side effects. When you keep giving your dog Clomicalm, see if it feels drowsy all the time or not. You can notice it by observing how active your dog has been lately. It will not be sleeping all the time, but will simply appear a bit fatigued.

Although it is not a concern, you can still consult with your vet to make sure everything is okay.

Can you stop Clomicalm?

Yes, you can stop Clomicalm, but not abruptly. Consult with your vet, and ask them to handle the stoppage. They will lower the dosage in an organized manner making it easier for you to gradually cut off the Clomicalm administration. It is as if you were releasing fish in a water tank; you cannot just release them in the water. You need to do so gradually.

You should stop giving your dog Clomicalm if it is having difficulty in breathing, has an irregular heartbeat, seizures, fever, weakness, swelling of the face, or muscle stiffness. Immediately consult your veterinarian for further advice afterward.

Does Clomicalm work for cats?

Yes, Clomicalm will work for cats.

However, do not give it to them without seeing a vet first. Since it is a prescription drug, you need to maintain every bit of caution necessary when it comes to using it.

Is Clomicalm a TCA?

Yes, Clomicalm is a TCA tricyclic antidepressant. It is used to handle issues related to stress, anxiety, and destructive behaviors in dogs. TCAs work by increasing the amount of serotonin in the brain.

Can traZODone be taken with Clomicalm?

No, traZODone should not be taken with Clomicalm unless specifically prescribed by the vet.

Using the two medications together can lead to serotonin syndrome, where the dog may suffer from confusion, seizure, hallucinations, etc. So it is best to avoid using these two together.

Can a dog overdose on Clomicalm?

Yes, dogs can overdose on Clomicalm.

A Clomicalm overdose can lead to a decrease in activity. Your dog will start trembling. Under extreme overdose conditions, their eyes might become droopy.
Concluding Thoughts

The most important thing that you should know about Clomicalm is its power to be effective treatment for undesirable behavioral issues in your dogs, such as separation anxiety, aggressive and destructive behavior, and other anxiety-related issues. Clomicalm is the advocate to calm your dogs in stressful situations.

DISCLAIMER: FDA law restricts Clomicalm only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian whether Clomicalm is suitable for your dog. Ask your licensed veterinarian to prescribe an exact dosage and other specifications prescribed for your dog.

Clomicalm 40mg has been discontinued by the manufacturer. Please speak to your Veterinarian about a different dosage.

Clomicalm is the Generic Alternative to Anafranil.

Side Effects & Warnings

Clomipramine has several adverse side effects such as lethargy/depression, elevation in liver enzymes, vomiting, diarrhea, and increased thirst. Clomicalm may cause drowsiness. Stop giving your pet Clomicalm and contact your vet if the pet experiences difficulty breathing, hives, irregular heartbeat, difficulty urinating, seizures, fever with increased panting, muscle stiffness or weakness, or swelling of the lips, tongue, or face.

Clomipramine is not authorized to be used in breeding dogs. Attention should be paid to breeding dogs suffering from cardiovascular dysfunction, epilepsy, narrow angle glaucoma, reduced gastrointestinal motility or urinary retention. Clomipramine should be prescribed with extreme care, only after making a true assessment of the benefit and the risks associated with the medication. Clomipramine is not advisable when consumed in combination with monoamine oxidase inhibitors. Never use Clomipramine or any other tricyclic antidepressants in animals that are allergic to it. Do not use Clomipramine in pregnant, nursing or breeding females, or with other central nervous system (CNS) depressants such as barbiturates. Inform the veterinarian about what other medications the pet is taking.


Clomipramine Hydrochloride


This tricyclic antidepressant medication helps to tackle behavioral problems in cats and dogs. The medication intake happens orally as per a prescribed dosage to treat behavioral issues of the pets. It is a prescription drug that can help tackle obsessive-compulsive behavior, dominance aggression, or separation anxiety among pets. In cats, it can specifically help to take care of using marking or spraying and reduce inter-cat aggression.



The use of the medication happens in the pads to control separation anxiety and help provide behavior modification. It also helps tackle destructive behavior, inappropriate aggression, defecation, and inappropriate urination. 

Special Precautions

The use of the drug should not happen in their pets that have an allergy to Clomipramine. The same applies to any other tricyclic antidepressants. If any monoamine oxidase inhibitors are currently used, this medication should not be given to your pet. It is advisable to avoid the medicine if your pet is aging and if they have a history of seizures. Breeding males should also avoid this medication, and caution is advisable for the pets.

Giving medication to pets that have a prevailing condition should happen cautiously. These conditions can include glaucoma, aggression, overactive thyroid, decreased gastrointestinal movement, dry eye syndrome, difficulty urinating, adrenal tumors, heart disease, diabetes, and liver disease. Caution is also advisable for lactating and pregnant pets that are old or very young.

Mechanism of Action

The elevated neurotransmitter serotonin due to the action of clomipramine in the brain helps trigger a different response and tackle the issues. The class of medication gets classified as a tricyclic antidepressant because it is a tree rings structure that can affect several neurotransmitters—the compound serotonin links to a feeling of happiness and comfort. The action of the drugs innovates the removal of serotonin in the brain to keep it for longer.

Known Drug Interactions

Caution is advisable for administering the medication with other drugs, including NSAIDs, antifungals, sympathomimetic agents, butyrophenone antipsychotic agents, anticholinergic agents, and monoamine oxidase inhibitors. Alteration of blood glucose levels also takes place after starting this medication.

Brand/Generic Equivalents



Clomipramine is administered orally at a usual dose of 1 - 2 mg/kg, clomipramine twice daily to give a total daily dose of 2 - 4 mg/kg. The medicine is available in oral, beef flavored tablets of 3 strengths: Clomicalm 5, 20 and 80 containing 5.00 mg, 20.00 mg and 80.00 mg clomipramine hydrochloride, respectively. Clomipramine is available by prescription in the form of tablets and capsules. The usual dosage of Clomipramine in dogs is 0.9-1.8mg/pound every 24 hours.

Administer Clomicalm to the exact specifications prescribed by veterinarian. Give Clomicalm orally with food and lots of water.

Dogs: Weight / Dosage

11-22 Lbs / One 20mg tablet daily
22.1-44 Lbs / One 40mg tablet daily
44.1-88 / One 80mg tablet daily
88.1-176 / Two 80mg tablets daily

Need Help? Call 1-866-893-0306