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Product Description

Ultimate Guide to Clomicalm

Meet the Canine Behavioral Conditioner: Clomicalm!

Clomicalm is an FDA-approved, veterinarian-recommended, prescription anti-depressant for dogs. Clomicalm is intended to treat separation anxiety, obsessive compulsive disorder (OCD), and other undesirable behavioral conditions in dogs. Use Clomicalm as a behavior modification tool to calm your dog in stressful situations.

How does Clomicalm work?

Clomicalm is a medication with one active ingredient - Clomipramine Hydrochloride.

Clomipramine Hydrochloride is a tricyclic antidepressant that works by restoring the balance of certain natural substances in the brain, including the happy chemical or feel good hormone serotonin. Clomipramine for dogs is the first FDA-approved generic substance that treats separation anxiety and any behavioral condition in dogs.

The prescription drug Clomicalm, a generic alternative for Anafranil, eliminates certain undesirable behavioral issues in dogs, including separation anxiety, OCD, excessive barking, aggressive or destructive behavior, and eliminating (urination or defecation) at inappropriate times. Most importantly, Clomicalm aids your dog in stressful situations.

How is Clomicalm administered?

Clomicalm is administered twice daily with food and lots of water. Your licensed veterinarian will prescribe the exact dosage and other specifications prescribed by your veterinarian. The usual dosage is with one to two mg per pound. Clomicalm are oral, beef flavored tablets and capsules of the active ingredient Clomipramine Hydrochloride.

The tablets come in 20 mg (blue), 40 mg (purple), and Clomicalm 80 mg (green) of Clomipramine Hydrochloride, and the dog is administered which tablet depending on their bodyweight. See the dosage chart below.

Body Weight

20 mg

40 mg

80 mg

11 - 22 lbs.


22.1 - 44 lbs.


44.1 - 88 lbs.


88.1 - 176 lbs.


What are Clomicalm side effects of which you should be aware?

Clomicalm may cause drowsiness.

Stop giving the medication Clomicalm and contact your vet if the pet experiences difficulty breathing, hives, irregular heartbeat, difficulty urinating, seizures, fever with increased panting, muscle stiffness or weakness, or swelling of the lips, tongue, or face.

Frequently Asked Questions 
  1. How long can it take to see effective results in Clomicalm for dogs?

    Clomicalm's first therapeutic effects in dogs can be observed in two weeks. It can take 6 to 12 weeks to treat OCD behavior. It may take four to six months to see the full effect of this medication. Since Clomicalm takes time to work, do not increase, decrease, or stop without discussing with the veterinarian.

  2. What do the Clomicalm or Clomipramine reviews say?

    Clomicalm reviews rate 4.5 stars out of 5 stars. Most reviewers say that their dog seems like a different dog, like night and day, a happier and calmer dog.

  3. Is Clomipramine for cats?

    Clomicalm is specifically designed for dogs ONLY, but YES! Cats can take Clomipramine to treat OCD and other anxiety-related conditions. Therapeutic levels are reached after approximately five to seven days of treatment. Read the following article Using Clomipramine Hydrochloride - Behavior Issues about Clomipramine for cats.

  4. What is the Clomicalm dosage?

    Clomicalm is administered a usual dosage of one to two mg per pound twice a day with food and lots of water. Your licensed veterinarian can administer an exact dosage and other specifications suitable for your dog.

  5. Is Clomicalm for puppies?

    Clomicalm can be administered to puppies that are at least 6 months and older, basically those who are old enough to train.

Concluding Thoughts

The most important thing that you should know about Clomicalm is its power to be effective treatment for undesirable behavioral issues in your dogs, such as separation anxiety, aggressive and destructive behavior, and other anxiety-related issues. Clomicalm is the advocate to calm your dogs in stressful situations.

DISCLAIMER: FDA law restricts Clomicalm only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian whether Clomicalm is suitable for your dog. Ask your licensed veterinarian to prescribe an exact dosage and other specifications prescribed for your dog.

Clomicalm 40mg has been discontinued by the manufacturer. Please speak to your Veterinarian about a different dosage.

Clomicalm is the Generic Alternative to Anafranil.

Side Effects & Warnings

Clomicalm may cause drowsiness. Stop giving your pet Clomicalm and contact your vet if the pet experiences difficulty breathing, hives, irregular heartbeat, difficulty urinating, seizures, fever with increased panting, muscle stiffness or weakness, or swelling of the lips, tongue, or face.


Clomipramine Hydrochloride


Administer Clomicalm to the exact specifications prescribed by veterinarian. Give Clomicalm orally with food and lots of water.

Dogs: Weight / Dosage

11-22 Lbs / One 20mg tablet daily
22.1-44 Lbs / One 40mg tablet daily
44.1-88 / One 80mg tablet daily
88.1-176 / Two 80mg tablets daily

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