Requires Rx

Free delivery

Typical Consumer

Members Save $/yr

Member Price
Cannot be combined with other offers

Every time a new member signs up, we will donate a FREE membership to a Best Friends adopted animal. Best Friends is America's largest animal sanctuary.

Get all these benefits with $99 annual membership


Our customers typically save close to $200/yr when purchasing preventatives as members of PetPlus.

PetPlus is a membership plan that gives you wholesale pricing on preventatives, supplements and speciality foods.
With Free Shipping always, no minimums.

Why Become A Member? Additional Ways To Save With PetPlus

Typical Annual Savings "For Your Pet

Typical Annual Cost $40 $190 $95 $112 $200
PetPlus Annual Cost $12 $110 $55 $68 $150
  Sample Annual PetPlus Savings $28 $80 $40 $44 $65
Typical Annual Cost
PetPlus Annual Cost
Sample Annual PetPlus Savings

We're Here to Help You Every Step of the Way

average savings

$242 / YR

Wholesale Prices on Pet Medication & Supplements
Free 24/7 Pet Help provided by whiskerDocs
Wholesale Prices on RX & Premium Foods and Treats
Convenient Medication Pickup Option
Free Delivery on Medication
Product Description

Ultimate Guide to Betagen

Meet the Bacterial Skin Sprayer: Betagen!

Betagen is an FDA-approved, veterinarian-recommended, anti-inflammatory medication that aids dogs suffering from skin lesions caused by bacterial infections. Betagen is a daily, topical spray that helps treat and relieve hot spots, rashes, skin infections, and allergies.

How does Betagen work?

Betagen is a topical spray with two active ingredients - an antibiotic Gentamicin Sulfate and an anti-inflammatory Betamethasone Valerate. Together, these superhero active ingredients kill a variety of bacterial skin infections.

Gentamicin Sulfate is a highly potent, broad-spectrum aminoglycoside antibiotic that treats bacterial infections by stopping bacterial growth, both Gram-negative and Gram-positive. Aminoglycosides enter the bacterial cell wall, inhibit its protein synthesis (i.e., bacteria production), and cause the bacterial cell to die.

Betamethasone Valerate is an anti-inflammatory corticosteroid that treats a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash) by activating natural substances in the skin to reduce swelling, redness, and itching.

How is Betagen administered?

Betagen is for topical use on dogs ONLY. Before treatment, remove excess hair and clean the lesion. Hold the bottle three to six inches away from the bacterial lesion. The usual dosage* is two depressions of the spray nozzle 2 to 4 times a day for 7 days.

Each milliliter of the spray contains 0.57 mg of Gentamicin Sulfate, 0.284 mg of Betamethasone Valerate, and 163 mg of isopropyl alcohol, propylene glycol, methylparaben and propylparaben preservatives, and purified water.

*Your licensed veterinarian will inform you how many sprays to give your dog daily and how long the treatment should last for.

What are the precautions of which you should be aware?

The Betagen topical spray is safe for dogs with sensitive skin, however, do not use the product if your dog:

  • Has a viral or fungal infection (i.e., only treats bacterial infection)
  • Is pregnant or lactating
  • Is using other antibiotics or corticosteroid medications
What are the potential side effects of which you should be aware?

Betagen Topical Spray side effects are rare, such as polydipsia, increased urination, vomiting, diarrhea, and weight loss. Talk to your veterinarian if you notice any unusual side effects.

Frequently Asked Questions
Can Betagen Be Used for Cats?

Betagen Otic Solution treats acute and chronic otitis externa and superficial infected lesions in both dogs and cats. These conditions are caused by bacterias, which are sensitive to gentamicin.

In simpler terms, the topical spray is used to treat and relieve conditions like allergies, rashes, skin infections, and hot spots. Betagen topical spray for cats is a prescription medicine and can be used short-term for cats as per the directions from the veterinarian.

Can You Use Betagen in Dog's Ears?

Betagen topical spray is meant only for external use to treat allergies, skin infections, hot spots, and rashes. If your dog has any of these conditions inside the ear, it would be best to consult your vet.

There's no alternative like Betagen topical spray for dog's ears, so stay away from products being market like that. Any prescription medicine like Betagen spray should be administered only as directed by a licensed vet.

Does Betagen Topical Spray Sting

Betagen is a safe topical antibiotic spray for dogs. The dog topical spray should not cause any pain on contact usually and not sting. If your dog is reacting strongly to the Betagen medicine, then consider the possibility of allergy to the Betagen Topical Spray ingredients.

Don't stop the suggested dosage by your veterinarian just because your dog is acting like it's painful. Consult your vet to discuss what is causing this reaction and to find out how to continue treating the infection without causing pain to your furry friend.

What Is Betagen Topical Spray Used for in Dogs?

The Betagen topical spray has an antibiotic called gentamicin and an anti-inflammatory called Betamethasone. This makes Betagen an antimicrobial and corticosteroid. The medication is used on canine and feline animals to tread superficial lesions caused by bacteria. The spray can heal various skin conditions like rashes, hot spots, and infections.

Can Betagen Be Used on Dog Paws?

Yes, Betagen can be used on dog paws if instructed by your vet. The medicine is intended to treat bacterial infections and rashes and prove to be effective if your dog has these conditions on its paws. However, don't use Betagen if your dog has a fungal infection.

Can I Use Betagen Topical Spray on a Wasp Sting?

No, Wasp Stings are puncture wounds with a small amount of poison injected inside the body. Betagen Topical Spray is meant to treat external skin conditions like rashes and infections. In case of wasp stings, rush your pet to the vet and get treatment started as soon as possible. Usually, a wasp sting may cause general weakness, difficulty in breathing, and a large amount of swelling.

Can My Dog Lick at Betagen Sprayed on Her Paw?

Usually, topical sprays dry too quickly for your dog to be able to lick it. However, try and stop your dog or cat from licking the infected site after spraying with Betagen. This is to ensure that the medicine gets the time to take effect and treat the infected area.

Do I Need a Prescription to Buy Betagen for Dogs?

Yes, Betagen Topical Spray for dogs and cats is an FDA-approved medication and requires a Betagen Spray prescription to purchase over the counter. It's in the best interest of the pet parent since Betagen spray is not meant for infections of all kinds.

For example, spraying Betagen Topical Spray on a fungal infection may worsen the condition. Therefore, always consult your vet and get directions as well as a prescription for the dog topical spray.

Does Betagen Topical Spray Cause Dog Diarrhea?

Betagen is an FDA-approved medication that is safe to use, but there are some Betagen topical spray side effects. You may witness side effects like diarrhea, vomiting, and weight loss, among others. In case you notice any unusual side effects, it's best to consult your vet.

Does Betagen Work Good For Road Rash on Dogs?

Betagen is a topical spray that aids in treating and relieving hot spots, rashes, skin infections, and allergies in your canine or feline friend. As long as the infection is external and not fungal, the topical spray should work. However, you will need to consult your veterinarian and show the road rash to ensure that Betagen is required and recommended dosage.

How Many Times Can You Spray Betagen Spray a Day?

The usual dosage for the Betagen topical spray is two sprays, two to four times a day. However, the dosage will depend on the severity of the condition and other factors. You'll need to consult with an excellent veterinarian to get recommended dosage and prescription for the topical spray.

Concluding Thoughts

The most important thing that you should know about Betagen topical spray is its power to comfort your pup and eliminate your dog 's skin irritable or painful inflammations from bacterial infections.

DISCLAIMER: FDA law restricts Betagen to use by or on the order of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article does not substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Betagen is a prescription medication for dogs.

Side Effects & Warnings

While serious side effects are not typical, extended use of Betagen Spray may result in the growth of organisms such as fungi and yeasts.

Following the use of synthetic corticosteroids, some animals experience increased thirst and urination, vomiting and diarrhea, and weight loss.

Talk to your veterinarian if you notice any unusual side effects.

Do not use Betagen Topical Spray if your dog has a viral or fungal infection.

Talk to your veterinarian if your dog is pregnant or lactating.

Consult with your veterinarian before using Betagen Spray if your dog is taking other antibiotic or corticosteroid medications. Talk to your veterinarian before administering any other medications while using Betagen Spray


Each mL contains: gentamicin sulfate equivalent to 0.57 mg gentamicin base, betamethasone valerate equivalent to 0.284 mg betamethasone, 163 mg isopropyl alcohol, propylene glycol, methylparaben and propylparaben as preservatives, purified water q.s. Hydrochloric acid may be added to adjust pH.


  • Your veterinarian will inform you of the number of sprays per day and the duration of treatment.

  • The usual dose is 2 sprays 2-4 times a day for 7 days.

  • Do not use Betagen Spray for more than 7 days unless advised by your veterinarian.

  • Prior to treatment, remove excess hair and clean the lesion and surrounding area.

  • To use, hold the spray bottle 3 to 6 inches from the affected area.
  • Need Help? Call 1-866-893-0306