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Product Description

What is Apoquel?

Apoquel is a fast acting and safe new treatment from Zoetis for the control of acute and chronic canine pruritus.

Apoquel provides onset of relief within 4 hours and effectively controls itching within 24 hours. It is safe for short term and long term use and can be used in combination with many other medications. Uniquely targeted to stop the itch with minimal negative impact on the immune function. According to genuine Apoquel reviews by customers, it improved the quality of life for the dog and its owner.

APOQUEL inhibits the function of a variety of pruritogenic and proinflammatory cytokines, as well as cytokines involved in allergy that are dependent on JAK1 or JAK3 enzyme activity4.

Apoquel Dosage for Dogs

Apoquel for dogs dosage depends on the weight of your pet. It comes in three dosages, Apoquel 16 mg, 5.4 mg, and 3.6 mg. Depending on the size of your pet, vets may recommend breaking a tablet in half to administer the right dosage.

For instance, dogs that weigh 9.9lbs or less are recommended a dosage of 1.8 mg. This means pet owners need to break an Apoquel 3.6 mg tablet in half to attain the accurate dose. Giant breeds may need two tablets of Apoquel 16mg for dogs. Check the dosing chart for details.

The size of the tablets is incremental with dosage. This allows easy administration and it ensures the size of the tablet is perfectly suited for the dog's size.

  • Apoquel 3.6 mg for dogs is 10 mm
  • Apoquel 5.4 mg for dogs is 17 mm
  • Apoquel 16 mg for dogs is 19 mm

Apoquel Dosing Chart

Apoquel Dosage (Number of Tablets)


Apoquel 3.6 mg

Apoquel 5.4 mg

Apoquel 16mg

6.6 to 9.9 lbs



10 to 14.9 lbs




15 to 19.9 lbs



20 to 29.9 lbs




30 to 44.9 lbs



45 to 53.9 lbs




54 to 59.9 lbs




60 to 89.9 lbs



90 to 129.9 lbs


One and a Half

130 to 175.9 lbs




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Side Effects & Warnings

APOQUEL® should not be used in dogs less than 12 months of age or in dogs with serious infections. APOQUEL may increase susceptibility to infection and demodicosis and may exacerbate neoplastic conditions. APOQUEL has not been evaluated in combination with systemic immunosuppressive agents such as glucocorticoids or cyclosporine. APOQUEL should not be used in breeding dogs or pregnant or lactating dogs. The most common APOQUEL side effects in dogs post-administration were vomiting and diarrhea. APOQUEL has been safely used in conjunction with other common medications including antibiotics and parasiticides and with vaccinations.


The dose of APOQUEL tablets is 0.18 to 0.27 mg/lb (0.4 to 0.6 mg/kg) APOQUEL should be given twice daily for up to 14 days of therapy and once daily thereafter for maintenance APOQUEL may be given with or without food APOQUEL may be used concomitantly with many common therapies including vaccines, NSAIDs, antibiotics and allergen immunotherapy3

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