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Product Description

Allopurinol is a medication used in veterinary medicine to address various conditions in animals, ranging from the prevention of uric acid and calcium oxalate uroliths (stones) in dogs to treating leishmaniasis in dogs and cats. Additionally, it has been employed off-label to manage gout in certain avian and reptilian species.

  • Mechanism of Action:The medication functions by reducing the production of uric acid within the body. By inhibiting the enzyme xanthine oxidase, Allopurinol effectively decreases the formation of uric acid, thereby aiding in the prevention of urinary stone formation.

  • Administration and Formulation:Allopurinol typically comes in tablet form and is administered orally to animals. For avian patients, it may also be added to drinking water. It can be given with or without food, although administering it with a small amount of food is recommended if an animal experiences vomiting or discomfort when taken on an empty stomach.

  • Dosage and Timing:Effects of Allopurinol may not be immediately apparent and can take several weeks to manifest. In some cases, improvement may not be visibly obvious. Ensuring that the animal has access to fresh water during treatment is crucial. If a dose is missed, it should be administered as soon as possible. However, it is advised to skip the missed dose and resume the regular dosing schedule if it is nearing the next scheduled dose.

  • Side Effects and Considerations:Side effects from Allopurinol are uncommon in dogs and cats, although some animals may experience vomiting or other signs of gastrointestinal upset, such as lack of appetite or diarrhea. In dogs receiving higher doses, there is a risk of developing certain types of bladder stones known as xanthine stones. Caution should be exercised when administering Allopurinol to animals with pre-existing liver or kidney issues. It is not recommended in red-tailed hawks and should be approached cautiously in other raptors. Safety in breeding, pregnant, or nursing animals has not been established.

  • Long-term Use and Dietary Considerations:When utilized for the long-term prevention of stones in dogs, a low-purine diet is often recommended with Allopurinol therapy to further mitigate the risk of stone formation.

Allopurinol is a valuable tool in veterinary medicine for managing conditions related to uric acid production in animals. While generally well-tolerated, careful monitoring and consideration of potential side effects are essential to its administration, ensuring the well-being of the treated animals.

Allopurinol is a fast-acting prescription oral tablet, intended to prevent and dissolve urate bladder stones. Allopurinol is a xanthine oxidase inhibitor, which means it inhibits the production of uric acid, preventing the build up of the crystals in the urine that cause bladder and kidney stones.

Allopurinol works by preventing the conversion of protein purines to uric acid. While Allopurinol prevents bladder and kidney stones, it can also dissolve stones that have already formed, and also treats infection due to the blood parasite Leishmania.

Allopurinol is the generic alternative to Zyloprim.

Side Effects & Warnings

Seek emergency veterinary aid if your pet experiences an allergic reaction such as, hives, difficulty breathing, swelling of the face, lips, tongue or throat, blood in the urine, pain when urinating, a rash, eye irritation, fever, chills or joint aches or severe nausea or vomiting. Consult veterinarian if your pet experiences upset stomach or diarrhea, dizziness or drowsiness or an acute attack of arthritis, or anything out of the ordinary.

Ampicillin or amoxicillin may increase the risk of rash development. Notify your veterinarian if your pet is being given a thiazide diuretic, azathioprine, drugs used to treat cancer, cyclosporine, warfarin or theophylline. Consult to your veterinarian before administering additional prescription or over the counter medications.




Administer Allopurinol to the exact specifications prescribed by veterinarian. Give Allopurinol orally with water and food.


All Weights: 5mg per pound of body weight, once daily with food

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