Advantage II for Dogs

Advantage II for Dogs

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Product Description

Ultimate Guide to Advantage II for Dogs

Meet Dog's Most Trusted Flea and Lice Killer: Advantage II for Dogs!

Advantage II for Dogs is the veterinarian-approved dog medication with two strong active ingredients to protect your dogs from fleas and lice. Advantage II for Dogs is a once-a-month spot-on topical treatment that remains effective for the next four weeks after application.

How does Advantage II for Dogs work?

The medication works with two active ingredients: Imidacloprid and Pyriproxyfen.

Imidacloprid is the world's most used insecticide. Advantage II for Dogs attacks a flea's central nervous system causing paralysis and its imminent death. Pyriproxyfen is an Insect Growth Regulator (IGR) that prevents proper flea hatching and the healthy growth of flea larvae.

Once administered, the medication eradicates existing fleas or lice on your dog within the first 12 hours after application and protects your dog from new fleas or lice within two hours.

How is Advantage II for Dogs administered?

Advantage II for Dogs is a monthly topical formula that uses the spot-on treatment approach. Apply one to three spots on different locations along the dog's spine from between the shoulder blades to the base of the tail. Allow one hour for Advantage II to dry.

See the chart below to know the specific dosage for your dog depending on their body weight:

Weight Dosage
3 lbs. - 10 lbs. (Small Dogs) 0.4 mL (Green)
11 lbs. - 20 lbs. (Medium Dogs) 1.0 mL (Teal)
21 lbs. - 55 lbs. (Large Dogs) 2.5 mL (Red*)
55 lbs. + (Extra-large dogs) 4.0 mL (Blue*)

*Use several spots for a larger dog to avoid irritation.

Though the solution is considered waterproof, you must wait one hour for the solution to dry, and then you don't need to reapply after bathing, swimming, or petting your pup.

Which dogs should not use Advantage II for Dogs?

Pregnant and lactating dogs. Puppies under 7 weeks old or less than 3 pounds. Elderly dogs or those who are in a debilitated state. Be aware if your dog is allergic to any of the active ingredients. Lastly, keep out of reach of children or cats.

Consult your veterinarian prior to prescription. Other pesticides may not interact well with Advantage products.

What are the potential side effects of which you should be aware?

After the spot-on treatment application of Advantage II for Dogs, your furry best friend may experience skin irritation. If it persists or worsens, call your veterinarian immediately.

Frequently Asked Questions
  1. What is the Advantage flea effect?

    Advantage II for Dogs kills fleas and prevents infestations throughout the following four weeks. Advantage II for Dogs kills fleas and lice within 12 hours after application. In terms of new fleas and lice, these parasites die on contact within 2 hours and for 30 days after an application.

  2. What is the difference between Advantage II for large dogs, Advantage II for extra large dogs, and Advantage II for medium dogs?

    All formulas have the same percentages of the active ingredients (9.10% Imidacloprid, 0.46% Pyriproxyfen, and 90.44% other ingredients), but small dogs, medium dog, large dogs, and extra-large dogs require a different dosage depending on the dog's weight (see the chart above).

  3. What are the Advantage II for Dogs reviews?

    Advantage II for Dogs reviews rates the solution 4.5+ out of 5 stars. Most reviewers say that this is the only flea treatment that they trust, that it is an awesome product, and easy to use. Reach out to your vet if having any concerns or questions about your dog's use of Advantage II for Dogs.

  4. Is Advantage II for puppies?

    Advantage II for Dogs can be administered to puppies that are at least 7 weeks old and weigh 3 pounds.

  5. Is Advantage II for Dogs used for cats?

    No. Advantage II for Dogs is manufactured only for dogs. However, with the two other active ingredients (i.e., Imidacloprid and Pyriproxyfen), Advantage II for Cats is still a monthly topical solution that kills and prevents flea and lice infestations. The cat must be at least 8 weeks old and weigh 9 pounds.

Concluding Thoughts

The most important thing that you should know about Advantage II for Dogs is its power to kill lice, treat every life stage of the flea, and prevent future infestations for 30 days after one application. The medication guarantees happier, healthier, and more comfortable dogs.

DISCLAIMER: FDA law restricts Advantage II for Dogs only on order or prescription of a licensed veterinarian for the best pet health care advice. Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427. This informative article is not meant to substitute for the diagnosis, treatment, and professional advice from your veterinarian or other qualified professionals regarding a medical condition. Ask your veterinarian whether Advantage II for Dogs is suitable for your dog. Ask your licensed veterinarian to prescribe an exact dosage and other specifications prescribed for your dog.

Side Effects & Warnings

As with any topical treatment, skin irritation may occur as a result of using Advantage for dogs. If irritation does not subside or worsens, contact your veterinarian. Do not combine with other spot-on flea treatments, unless recommended by your veterinarian.

Ask your veterinarian or consult with one of our pet care specialists at 1-800-844-1427.

This information is for informational purposes only and is not meant as a substitute for the professional advice of, or diagnosis or treatment by, your veterinarian. Always seek the advice of your veterinarian or other qualified professional with any questions you may have regarding a medical condition. Never disregard or delay seeking professional advice due to what you may have read on our website. Our medications are FDA approved and/or EPA regulated when and as required by law.


Advantage for dogs contains Imidacloprid and Pyriproxyfen.


Advantage II for Dogs is intended for use on dogs and puppies 7 weeks and older. Medication should be applied once a month, being careful to give the correct dosage based on your dog’s weight.

Solution should be applied along the back of the dog, in 1-3 locations between the shoulders and base of the tail. The number of application spots should increase along with the weight of the dog (<20lbs = 1 spot, +20lbs = 2-3 spots). Part their fur and carefully apply solution directly to the skin, making sure there is no excessive run-off. Allow 1 hour for Advantage II to dry.

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