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You save: 55%

This product requires a prescription



  • 6 Pack


  • Mail-order

Product Details

About Trifexis 
Your dog is vulnerable to so many pests like fleas, worms, and parasites. Keep your dog healthier with Trifexis. Trifexis is a beef-flavored, chewable tablet for dogs that protects against heartworm, fleas, and intestinal worms, including hookworm, roundworm, and whipworm. Trifexis starts killing fleas within 30 minutes before they can lay eggs. It is administered once a month to your dog.

Key Benefits of Trifexis 

  • Kills fleas, prevents heartworm, and treats and controls intestinal parasites
  • Once monthly beef flavored chewable tablet
  • No isolation from other pets necessary

Who's Trifexis For? 
Dogs 5 pounds and heavier, and 8 weeks and older, who need protection against fleas, heartworm, hookworm, roundworm, and whipworm

Trifexis Ingredients 
Spinosad, Milbemycin oxime

How Does Trifexis Work? 
The active ingredient spinosad, a natural soil microbe, kills adult fleas by attacking the nervous system. Milbemycin oxime, a broad spectrum anti-parasitic, kills worms by attacking the neurotransmitters, causing hyperpolarization.

Side Effects and Warnings 
Adverse reactions include vomiting, itching, ear redness, skin redness and inflammation, loss of appetite, diarrhea, and lethargy. Use with caution in dogs with epilepsy. Puppies less than 14 weeks old may excessively vomit. Consult your veterinarian in regard to pregnant or lactating dogs. If dog experiences any listed effects, immediately contact your veterinarian. Not for breeds of collie.
Do not use ivermectin in addition to Trifexis. Consult your veterinarian regarding the addition of any other medication, supplement, or vitamins.

Trifexis Directions 
Dog must be tested by a veterinarian, and rid of worms, prior to taking Trifexis. Administer Trifexis orally according to prescribed dosage, based on weight.

PetPlus is not a pharmacy. PetPlus partners with National Association of Boards of Pharmacy (NABP) accredited pharmacies such as CVS, Walgreens, RiteAid and PetCareRx to fulfill your prescriptions. Prescription orders dispensed through online mail-order will be directed to PetCareRx, and those through in-store pickup will be dispensed at the local Caremark network pharmacy chosen by the customer.

*If by the end of the 1-year membership, you have not achieved total savings on all eligible purchases and services with the PetPlus Plan that is equal to or greater than membership fee, you are eligible for credit equal to the difference between membership fee and your total savings. See further detail in our Terms and Conditions.

**PetPlus works hard to make it easier for you to take care of your pet, and we don't want you to worry about costs. If you find a better price for an item from a U.S. licensed online pharmacy, we will do everything possible to meet or beat that price. Please call us at 1-866-893-0306 to speak with a customer care representative.